High-Fat Diet-Induced Colonocyte Dysfunction Escalates Microbiota-Derived Trimethylamine N-Oxide

Joo WJ, Zieba JK, Foegeding NJ, Torres TP, Shelton CD, Shealy NG, Byndloss AJ, Cevallos SA, 

Gertz E, Tiffany CR, Thomas JD, Litvak Y, Nguyen H, Olsan EE, Bennett BJ, Rathmell JC, Major AS, 

Bäumler AJ, Byndloss MX.

Science, 2021 Aug 13;373(6556):813-818.

Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface

Miller BM, Liou MJ, Zhang LF, Nguyen H, Litvak Y, Schorr EM, Jang KK, Tiffany CR, Butler BP, Bäumler AJ.

Cell Host & Microbe, 2020 Dec 9;28(6):789-797.e5.

Microbiota-Nourishing Immunity: A Guide to Understanding Our Microbial Self

Litvak Y, Bäumler AJ.

Immunity, 2019 Aug 20;51(2):214-224.

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

Velazquez EM, Nguyen H, Heasley KT, Saechao CH, Gil LM, Rogers AWL, Miller BM, Rolston MR, Lopez CA, Litvak Y, Liou MJ, Faber F, Bronner DN, Tiffany CR, Byndloss MX, Byndloss AJ, Bäumler AJ.

Nature Microbiology. 2019 Jun;4(6):1057-1064.

Comments in:

Mouse microbiomes: overlooked culprits of experimental variability, Genome Biology. 2019.

Outrunning Salmonella - the role of endogenous Enterobacteriaceae in variable colonization resistance, Lab Animal, 2019.

The founder hypothesis: A basis for microbiota resistance, diversity in taxa carriage, and colonization resistance against pathogens

Litvak Y, Bäumler AJ.

PLoS Pathogens, 2019 Feb 21;15(2):e1007563.

Microbiota-nourishing Immunity and Its Relevance for Ulcerative Colitis

Byndloss MX, Litvak Y, Bäumler AJ.

Inflammatory Bowel Disease, 2019 Apr 11;25(5):811-815.

Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition

Litvak Y, Mon KKZ, Nguyen H, Chanthavixay G, Liou M, Velazquez EM, Kutter L, Alcantara MA, Byndloss MX, Tiffany CR, Walker GT, Faber F, Zhu Y, Bronner DN, Byndloss AJ, Tsolis RM, Zhou H, Bäumler AJ.

Cell Host & Microbe, 2019 Jan 9;25(1):128-139.e5.

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification

Sorbara MT, Dubin K, Littmann ER, Moody TU, Fontana E, Seok R, Leiner IM, Taur Y, Peled JU, van den Brink MRM, Litvak Y, Bäumler AJ, Chaubard JL, Pickard AJ, Cross JR, Pamer EG.  

Journal of Experimental Medicine, 2019 Jan 7;216(1):84-98.

Colonocyte metabolism shapes the gut microbiota

Litvak Y, Byndloss MX, Bäumler AJ.

Science, 2018 Nov 30;362(6418).

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ.

Science, 2017 Aug 11;357(6351):570-575.

Comments in:

Gut cell metabolism shapes the microbiome, Science, 2017.

Microbiome: The microbiota maintains oxygen balance in the gut, Nature Reviews in Microbiology, 2017.

Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction

Litvak Y, Byndloss MX, Tsolis RM, Bäumler AJ.

Current Opinion in Microbiology, 2017 Oct;39:1-6.

Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway

Litvak Y*, Sharon S*, Hyams M, Zhang L, Kobi S, Katsowich N, Dishon S, Nussbaum G, Dong N, Shao F, Rosenshine I.

PLoS Pathogens, 2017 Jul 3;13(7):e1006472. *Equal contribution.

Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

Faber F, Thiennimitr P, Spiga L, Byndloss MX, Litvak Y, Lawhon S, Andrews-Polymenis HL, Winter SE, Bäumler AJ.

PLoS Pathogens, 2017 Jan 5;13(1):e1006129.


Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice

Dupont A, Sommer F, Zhang K, Repnik U, Basic M, Bleich A, Kühnel M, Bäckhed F, Litvak Y, Fulde M, Rosenshine I, Hornef MW.

PLoS Pathogens, 2016 May 9;12(5):e1005616.

Dynamics of expression and maturation of the type III secretion system of enteropathogenic Escherichia coli

Yerushalmi G, Litvak Y, Gur-Arie L, Rosenshine I.

Journal of Bacteriology, 2014 Aug;196(15):2798-806.


High catalytic efficiency and resistance to denaturing in bacterial Rho GTPase-activating proteins

Litvak Y, Levin-Klein R, Avner M, Selinger Z.

Biological Chemistry, 2011 Apr;392(6):505-16.

Aeromonas salmonicida toxin AexT has a Rho family GTPase-activating protein domain

Litvak Y, Selinger Z.

Journal of Bacteriology. 2007 Mar;189(6):2558-60.


Structure-function studies of the G-domain from human gem, a novel small G-protein

Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA.

FEBS Letters, 2006 Oct 30;580(25):5959-64.


Bacterial mimics of eukaryotic GTPase-activating proteins (GAPs)

Litvak Y, Selinger Z.

Trends in Biochemical Sciences, 2003 Dec;28(12):628-31.